Event

Abstract

-Reactions involving organic radical intermediates have been traditionally regarded as overly reactive and unselective. Nickel complexes can reversibly coordinate to radicals and modulate the reactivity and control the selectivity of reactions involving radical intermediates. Our mechanistic studies answer fundamental questions, such as "how do nickel complexes initiate radical formation from various precursors", "how do radicals interact with nickel complexes", and "How do ligands serve to stabilize open-shell intermediates and facilitate catalytic reactions?" Mechanistic insight has enabled us to develop novel catalytic methods for synthesizing noncanonical peptides and carbohydrates that are critical to drug discovery.

Research

Our research program encompasses organic, inorganic, and organometallic chemistry to solve issues in organic synthesis and energy research.

Our group focuses on solving long-standing problems in organic synthesis and sustainable energy research. We seek to provide strategically creative solutions through the development of transition metal catalysts. The rational design of catalysts is based on a thorough understanding of reaction mechanism. Driven by synthetic applications, we also synthesize and characterize new organometallic complexes with the goal of elucidating fundamental principles of molecular bonding.

https://www.diaogroup.org

HOST: Kozlowski