Continuation of CHEM 1101: General Chemistry Laboratory I

Theoretical and experimental aspects of important rate processes in chemistry.

The course encompasses the descriptive chemistry, and topics related to, the f-block including the rare earth metals and actinides. Coverage includes coordination chemistry and periodic trends, electronic structure and magnetism, and modern applications of f-block chemistry including lanthanide ions as spectroscopic probes, separations chemistry, materials chemistry and applications, organo-f-element chemistry, the chemistry of the actinides and transactinides, and reactivity/catalysis with f-block compounds.

This course will provide an introduction of structure-property relationships in materials chemistry on length scales from atomic dimension up to the microscale and then draw on examples of Chemical design for "Energy and Environmental Sustainability." We will introduce the "12 Principles of Green Chemistry" and "12 Principles of Green Engineering" as a guide to modern materials chemistry design and follow a trajectory that proceeds with increasing length scales of ordering in the solid state. We will introduce techniques of x-ray, neutron, electron, and ion beam based scattering, real space imaging and spectroscopies and use these to explore non-crystalline materials (amorphous, glasses, and time permitting quasicrystals and aperiodic systems) and crystalline solids. Studies will proceed from atomic scales through nanoscale, mesoscale, and micro-scale discussing the emergence of band structure and delcocalized electronic and optical properties that emerge due to the finite scale of ordering and influence of the surface. Select examples will be drawn from advances in materials for in solar energy utilization with photochemistry and photoelectrochemistry and materials for photovoltaic and enabling advances electrochemical energy conversion and storage.

A continuation of X-ray I. This course will focus on the practical component of X-ray crystallography. Students will use crystallographic software (OLEX2, CrysAlisPRO, ShelX suite) to solve, refine, and finish small molecule crystal structures. These will include case studies and crystallographic problems such as the various types of disorder and twinning.

An introduction to the theory and practice of small molecule structure determination by X-ray crystallography. Topics discussed include point group and space group symmetry, structure factor theory, data collection methodology and a survey of solution methods. The course will include case studies of real-world structure determinations and interpreting X-ray structures.

This course will introduce topics in Chemical Biology and pharmacology and how they are applied for both basic and translational research. The course is focused on how basic science technology can be applied to discover a drug. The main components include: (1) selection of a disease with a focus on rare diseases (2) selection of a drug target, and (3) determining whether or not a small molecule interaction with that target can be expected to produce a therapeutic response. Key concepts of small molecule drug discovery are discussed throughout the course. Key technologies such as chemical proteomics and targeted degradation are covered. The advantages and disadvantages of therapeutic small molecules versus biologics will be discussed.

This course will cover the theory and experimental implementation of parallel microscale experimentation used in the development of chemical reaction processes with a focus on organic chemistry transformations. Coverage includes the precepts behind design of experiment as well as errors commonly encountered in parallel microscale experimentation. Basic machine learning principles will be covered with the goal of selecting appropriate substrate/catalyst selection and generating predictive models using RDKit and Python. There is a laboratory component which may extend outside of listed class hours.

This course will provide an introduction to methods and applications of contemporary biochemical techniques and instrumentation used for analysis of biomolecules, including proteins, DNA/RNA and metabolites. Topics covered will include chromatographic and electrophoresis, mass spectrometry, fluorescence microscopy for the detection, characterization and structural analysis of proteins, antibodies and nucleic acids. The focus of the course will be applications in bioanalysis, biopharmaceuticals and biotechnology.

Natural products such as tetrodotoxin, kainic acid ,and morphine have played a crucial role in the development of neuroscience. Using selected chemical syntheses as a framework, I will provide an introduction to neuroscience for chemists blended with a course in synthetic design. The structure function and synthesis of the following molecules will be analyzed: tetrodotoxin, saxitoxin, kainic acid, nicotine epibatidine, coniine, histrionicotoxin, strychnine, chrysanthemic acid, morphine, salvinorin A, THC, lysergic acid, huperzin A. galanthamine, cocaine, reserpine, capsaicin. resiniferatoxin, retinal, carotene menthol, camphor and the prostaglandins. The structure and function of important ion channels, GPCRs transporters, and enzymes and their ligands will be discussed using PyMol files.
Goals: The goal of this course is to get as many synthetic chemists excited about neuroscience as possible (and a few neuroscientists stoked about synthesis). The importance of structural and pharmacological databases (PDB and IUPHAR, respectively)m and the usefulness of the Reaxys database (and SciFinder) for synthetic planning will be demonstrated.
Requirements: A familiarity with synthetic organic chemistry and (named) chemical reactions a mastery of the Nernst equation and a willingness to learn more about one of the greatest if not the greatest scientific challenges of our times: to figure out how the human brain works.