This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development.
Med Chem II builds on the material in Med Chem I and focuses on specific drug targets such as enzyme, G-protein coupled receptors, channels, nucleic acids and protein-protein interactions. Additionally, therapeutics area specific medicinal chemistry and drug discovery applications will be covered including anti-cancer agents, anti-infectives (antibiotics and anti-virals), and therapeutics to treat psychiatric and neurodegenerative disorders. This course is geared to upper level undergraduate students in chemistry or biochemistry and graduate students. Completion of Session I is a prerequisite.

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Topics include the drug discovery process, drug targets (GRCR?s, enzymes, channels etc.), physical chemistry of molecular interactions between drug and target, drug design, methods for hit and lead identification, lead optimization, chemical biology, natural products chemistry and combinatorial and diversity oriented synthesis. This course is geared to upper level undergraduate students in chemistry or biochemistry, and first year chemistry graduate students. A strong understanding of organic chemistry is required.

The course will focus on Essential Practical NMR for Chemistry. Topics will include structure elucidation with 1D and 2D NMR spectra, how to obtain high quality NMR spectra on spectrometers, data processing with NMR software such as MNova and TOPSPIN, multi-nuclei NMR including 31P, 19F, 11B, 15N and 2H etc., dynamic and kinetic NMR, and some techniques to provide high resolution 2D NMR spectra.

A Mass Spectrometry introductory course describing MS history, key ionization methods, mass analyzers, and MS methods for structure elucidation. The successful participant will be able to:
Extract key information from stable isotope distribution patterns.
Interpret key mass spectral fragment/product ions from a spectrum when acquired.
Understand the differences between the major ionization sources.
Understand the differences between the major mass analyzers.
Determine reasonable ionization methods and analyzers for a sample or project.

This course, for graduate students, encompasses topics in fundamental and applied photochemistry and photophysics from the fields of organic chemistry and chemical biology. Key topics and concepts will include basic photophysics, interactions of light with matter, UV-Vis absorption and emission spectroscopy, energy transfer, kinetics/dynamics, Jablonski diagrams, electron transfer, organic photochemistry, and applications in organic chemistry and chemical biology. These topics and concepts will be covered in the context of frontier applications including synthetic chemistry organic photochemistry, molecular imaging, and optogenetic tools among others.

This course examines the structure and organization of the chemical literature in the field of organic chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques, complex substructure and reaction search techniques, methods of using the literature for retrosynthetic analysis, and methods of retrieving property information and profiling substances by their properties. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in-depth discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in organic chemistry research.

This course examines the structure and organization of the chemical literature in the field of inorganic and materials chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques; advanced substructure and composition searches, with an emphasis on organometallic and inorganic substances and crystal structure data; reaction search techniques, focusing on catalyzed reactions; and methods of retrieving property information and profiling substances and materials by their properties. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in-depth discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in organometallic, inorganic, or materials chemistry.

Material in this course will survey the synthesis, structure, and chemical properties of inorganic complexes from across the periodic table. The content will make use of thermodynamic and kinetic data, in conjunction with molecular orbital theory, to understand trends in bonding. Density functional theory calculations will be performed by students (no experience necessary) to support key concepts developed in the course.

This course will outline the physical chemical basis for enzyme catalysis. The kinetics and thermodynamics of substrate and inhibitor interactions will be discussed prior to an examination of paradigm systems. Topics will include enzymes involved in the regulation of various cellular functions, including proteases, enzymes of natural products biosynthesis, and enzymes of epigenetics.

Physical and chemical description of macromolecular information transfer. Gene organization, replication, recombination, regulation and expression. (Formerly, CHEM 450-II).